In the early 20th century, the cultural heartland of Mithila & North Bihar recognized the urgent necessity of a dedicated institution to propagate scientific education and foster rational inquiry among youth.

Under the visionary patronage of the benevolent Raj Darbhanga and philanthropist citizen Babu Chandradhari Singh of Ranti-Deorhi, the foundation of Chandradhari Mithila Science College was ceremoniously laid in the year 1938.

The college commenced initially with Intermediate of Science (I.Sc.) courses and soon expanded to Bachelor of Science (B.Sc. Honours) and Master of Science (M.Sc.) programs across Physics, Chemistry, Mathematics, Botany, and Zoology. Over its eight decades of glorious service, the college has produced eminent scientists, Fellows of the Indian National Science Academy (INSA), civil servants, university vice-chancellors, renowned surgeons, and corporate leaders across the globe.